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What You Should Know About Gluten and Leaky Gut Syndrome

Posted by David Brady on

What You Should Know About Gluten and Leaky Gut Syndrome

A gluten-free diet as a lifestyle treatment for chronic illness has helped many patients recover from longstanding health issues. Despite some high-profile commentaries to the contrary, many doctors and nutritionist note success when they ask their patients to eliminate gluten from the diet. It's clear why this works for those with actual celiac disease, but the mechanisms are somewhat less clear for patients with gluten sensitivity, as well as those with no known gluten reactions. A recent study from the laboratory of Alessio Fassano, MD, at Harvard-Mass General may help illuminate the impact of gluten on the gut and its role in the development of issues unrelated to celiac disease.

The study explored the effects of the protein gliadin, a component of gluten (found in grains such as wheat, barley and rye) that triggers immune responses in some patients, on the integrity of the intestinal barrier (lining). Researchers took upper intestine (duodenal) biopsies from four populations: patients with active celiac disease, patients with celiac disease in remission, patients with gluten sensitivity, and patients with no known gluten reactions. In all of the groups, intestinal permeability was significantly increased ("leaky gut") by exposure to gliadin; altered gut barrier function was especially pronounced for those with active celiac disease and those with gluten sensitivity.

These findings suggest that even for people who lack known issues with gluten, eating gluten may increase intestinal permeability. In 2013, IFM presented Dr. Fassano with the Linus Pauling Award in Functional Medicine for his discovery of the connection between intestinal permeability and autoimmune diseases, including celiac disease. His research indicates that many autoimmune diseases develop in the presence of three factors: genetic predisposition, environmental trigger(s), and intestinal permeability (“Leaky Gut Syndrome”). If the findings of his research are corroborated, anyone who eats gluten could be increasing their risk of any autoimmune disease to which their genes make them susceptible through changes in intestinal permeability.

You can help avoid triggering of autoimmune diseases and inflammation of the gut even if you have not decided to follow a gluten-free diet by feeding the cells that line the intestine so they can be healthy and happy. GI-Vive, by Formulated Nutriceuticals, is designed as a daily supplement powder (mixed into water or any beverage) to maintain a healthy and vibrant gut lining.


    GI-Vive is a blend of nutrients and botanicals that support the health of the gastrointestinal (GI) tract. Modern diets and lifestyles can aggravate the lining of the GI tract with chemicals, allergens and bacteria. A healthy GI system acts as the body’s first line of defense, supporting proper digestion and immune function, and promoting optimal wellness.
    An easy-to-use powder that tastes great in any beverage and contains the health-promoting polyol xylitol as a sweetener.























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    • Hello,

      I just wrote a long post and somehow deleted most of it prior to posting.

      First and foremost, thank you for this amazing information and efforts to help people with fibromyalgia.

      There is a lot of research coming out about the link between fibromyalgia and Lyme disease. For example,

      I was diagnosed with fibromyalgia prior to being diagnosed with Lyme disease. As you know, fibromyalgia is a clinical diagnosis. So is Lyme disease, although it can be supported with lab tests.

      As with people who have fibromyalgia, many people with Lyme disease are gluten and casein free to help reduce symptoms.

      It would be amazing if you and other doctors like you could look into the link between fibromyalgia and Lyme disease and help many others.

      Again, thank you for all you do to help people with fibromyalgia.


      WN on this test

      WB on this test
    • Thank you for your comment Lisa. All of the ingredients are fully disclosed and listed if you click on the product name in the blog. It takes you to the product specific page in the store with the full supplement facts panel which lists every single ingredient. I am glad you brought up xylitol. While some polyols can cause some loose stools when taken at high doses buy some sensitive people, xylitol generally does not unless taken a doses significantly higher than what had been in this product. However, while the last sentence of the product description in the blog references xylitol, it was actually removed from this product a while ago and that sentence was not removed from this product description. The ingredients listed in the supplement facts panel for the product are 100% accurate though. I apologize for that error in The last sentence of the product description in the blog. Thank you for pointing that out to us. The product is now sweetened entirely with Stevia. It should be noted though that xylitol has many medicinal properties, including helping with bone density and reducing dental caries. As far as L-glutamine is concerned, this is a critically important amino acid for the cells that line the gut. In fact, it is their most preferred source of energy and without it the intestinal lining tissues degrade rapidly. Therefore, L glutamine is contained in this G.I. mucosal reviving product. I do understand given your complex history if you have intolerances to any of these ingredients, and that is why all ingredients are disclosed on the supplement facts sheet. However, for the vast majority of patients trying to improve got health this formula is amazingly effective. I have used it in my practice for over a decade since I formulated it with spectacular results and very few people who had any issues while taking it. I hope this clarifies the issues a bit for you and others. Dr. Brady.

      Dr. David Brady on this test
    • I’m confused. I thought xylitol, an alcohol sugar, causes diarrhea and gas in some people. I’m hesitant to try this formulation for that reason alone, also because you didn’t list what’s in this formulation. As a person who has IBD that is in remission – (I’ve had three flares in 25 years) – non-celiac gluten sensitivity, and type 2 diabetes, also in remission, there are specific things I don’t tolerate well, the amino acid, L-glutamine is one. I’m fine with you not posting my comment. I’m primarily writing to let you know that your endorsement of the product is fine, but you need to be more forthcoming with information.

      Lisa on this test

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